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Dendritic Spines$
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Rafael Yuste

Print publication date: 2010

Print ISBN-13: 9780262013505

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013505.001.0001

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Calcium

Calcium

Chapter:
(p.132) (p.133) 7 Calcium
Source:
Dendritic Spines
Author(s):

Rafael Yuste

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262013505.003.0007

This chapter explores calcium dynamics in spines. It explains that spines compartmentalize calcium, and this can create input-specific synaptic plasticity. It further points out that calcium influx into spines is regulated by voltage-sensitive calcium channels, N-methyl-D-aspartate (NMDA), and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The chapter then concludes that although spines generate input-specific calcium compartmentalization, input-specific calcium compartmentalization also occurs in neocortical interneurons without the help of spines.

Keywords:   spines, calcium, N-methyl-D-aspartate, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

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