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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine

Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine

Chapter:
(p.227) 18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine
Source:
Cerebral Plasticity
Author(s):

Partridge John G.

Vicini Stefano

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0018

This chapter investigates the modulation of synaptic N-methyl D-aspartate (NMDA) receptors in striatal medium spiny neurons by the presence of endogenous dopamine. It demonstrates that an interaction is occurring between ascorbate and dopamine. It also illustrates that ascorbate could facilitate the lifetime of dopamine acting synaptically by altering the oxidation state of dopamine (DA). This chapter then shows a novel regulation of NMDA receptor-mediated synaptic responses that may have relevance for neurological diseases of the basal ganglia.

Keywords:   N-methyl D-aspartate receptors, spiny neurons, dopamine, ascorbate, oxidation state, synaptic responses, neurological diseases, basal ganglia

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