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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation

Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation

Chapter:
(p.303) 24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation
Source:
Cerebral Plasticity
Author(s):

Graziano Alessandro

Jones Edward G.

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0024

This chapter describes the sprouting hypothesis, underlining its inadequacy in the face of experimental and clinical evidence. It presents the atrophy view and illustrates its potential for explaining both short- and long-term cortical plasticity after central and peripheral denervation. It demonstrates that transneuronal atrophy and withdrawal of the axons of deafferented neurons from centers higher in the somatosensory pathway is likely to contribute to cortical reorganization. This chapter suggests that a neurodegenerative process leading to anatomical and functional reorganization of thalamus and cortex at all stages of peripheral and central deafferentations likely to be a powerful inducement of representational plasticity.

Keywords:   cortical plasticity, peripheral denervation, transneuronal atrophy, deafferented neurons, somatosensory pathway, cortical reorganization, thalamus, cortex, deafferentations

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