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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation

Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation

Chapter:
(p.315) 25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation
Source:
Cerebral Plasticity
Author(s):

Hugh Perry V.

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0025

This chapter deals with the effect of systemic inflammation on neurodegenerative disease. It demonstrates that inflammation may contribute to Alzheimer’s disease (AD) progression. This chapter shows that the interactions between systemic inflammation and the microglia might have a profound influence on the acute and chronic phases of a neurodegenerative disease. It supports the hypothesis that systemic inflammation may accelerate the rate of decline in cognition in patients with AD. It shows that environmental enrichment can have a profound effect on the developing and diseased brain.

Keywords:   systemic inflammation, Alzheimer’s disease, microglia, neurodegenerative disease, cognition, environmental enrichment

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