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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Neurotrophins as Regulators of Visual Cortical Plasticity

Neurotrophins as Regulators of Visual Cortical Plasticity

Chapter:
(p.343) 27 Neurotrophins as Regulators of Visual Cortical Plasticity
Source:
Cerebral Plasticity
Author(s):

Castrén Eero

Fernando Maya Vetencourt José

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0027

This chapter describes neurotrophins as regulators of visual cortical plasticity. It illustrates that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are popular candidate molecules for synaptic plasticity. It supports the hypothesis that antidepressant drugs might increase neuronal plasticity in the cortex at least partially by activating BDNF signaling in brain. This chapter also shows the role of antidepressants as enhancers of plasticity, which is consistent with the fact that these drugs are successfully employed for the treatment of many neuropsychiatric disorders in addition to depression, including anxiety, obsessive-compulsive disorder, chronic pain, and eating disorders.

Keywords:   neurotrophins, visual cortical plasticity, brain-derived neurotrophic factor, nerve growth factor, synaptic plasticity, antidepressant drugs, neuronal plasticity, cortex

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