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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Suppression of Nogo-A to Enhance CNS Repair

Suppression of Nogo-A to Enhance CNS Repair

Chapter:
(p.367) 29 Suppression of Nogo-A to Enhance CNS Repair
Source:
Cerebral Plasticity
Author(s):

Willi Roman

Schwab Martin E.

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0029

This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after Nogo-A blockade and its implications for clinical application. This chapter shows that targeting the signaling components by appropriate blockers can prevent growth cone collapse and growth inhibition induced by Nogo-A and several other inhibitors. It also suggests that neutralization of the most potent of inhibitory molecules, Nogo-A, in animal models of spinal cord injury (SCI) and stroke has been shown to be effective in triggering axonal repair mechanisms and behavioral improvements.

Keywords:   central nervous system, Nogo-A, signaling pathway, neurite, growth inhibition, spinal cord injury, stroke

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