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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders

Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders

Chapter:
(p.75) 7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders
Source:
Cerebral Plasticity
Author(s):

Wilson Nathan R.

Mriganka Sur

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0007

This chapter deals with the control signals that command adjustments in the cortical circuits’ “plasticity status.” It outlines several “feedforward” mechanisms that can initiate circuit change, together with a host of emerging “feedback” network processes that respond to those changes. This chapter shows a rich array of mechanisms by which changes in input activity lead to changes in the structure and function of the synapses, cells, and circuits of the cortex. It then discusses several disorders of brain development, namely Rett syndrome, tuberous sclerosis, and Fragile X.

Keywords:   cortical circuits, synapses, cells, cortex, Rett syndrome, tuberous sclerosis, Fragile X

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