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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling

Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling

Chapter:
(p.89) 8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling
Source:
Cerebral Plasticity
Author(s):

Josh Huang Z.

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0008

This chapter hypothesizes that brain-derived neurotrophic factor (BDNF) acts as an activity-dependent retrograde signal to regulate synapse growth. The influences of altering γ-aminobutyric acid (GABA) synthesis on the development of perisomatic synapses from parvalbumin-containing (PV) basket interneurons in the visual cortex are explored. This chapter shows that GABA acts beyond inhibitory transmission in the juvenile and adolescent brain and regulates the maturation of inhibitory synapses and innervation patterns. It suggests that GABA receptors contribute to the activity-dependent regulation of synapse density. It also reveals that activity-dependent transcription may result in the adjustment of glutamic acid decaboxylase (GAD) 67 levels and the intracellular GABA pool for release.

Keywords:   brain-derived neurotrophic factor, γ-aminobutyric acid, perisomatic synapses, parvalbumin, visual cortex, inhibitory synapses, innervation patterns, basket interneurons

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