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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases

Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases

Chapter:
(p.101) 9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases
Source:
Cerebral Plasticity
Author(s):

Cristo Graziella Di

Chattopadhyaya Bidisha

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0009

This chapter concentrates on the mechanisms regulating the onset of ocular dominance (OD) plasticity. It describes how alteration in the timing of the critical period can be implicated in neurodevelopmental diseases. It reveals a critical role for basket cell interneuron maturation in the onset of critical period plasticity. This chapter shows that maturation of GABAergic inhibition regulates the onset of the critical period for OD plasticity in the visual cortex. It suggests that alterations in molecular pathways involved in regulating critical period plasticity are linked with neurodevelopmental diseases.

Keywords:   ocular dominance, plasticity, critical period, neurodevelopmental diseases, basket cell interneuron, GABAergic inhibition, visual cortex, molecular pathways

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