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Single Neuron Studies of the Human BrainProbing Cognition$
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Itzhak Fried, Ueli Rutishauser, Moran Cerf, and Gabriel Kreiman

Print publication date: 2014

Print ISBN-13: 9780262027205

Published to MIT Press Scholarship Online: January 2015

DOI: 10.7551/mitpress/9780262027205.001.0001

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Microstimulation Effects on Thalamic Neurons

Microstimulation Effects on Thalamic Neurons

Chapter:
(p.295) 16 Microstimulation Effects on Thalamic Neurons
Source:
Single Neuron Studies of the Human Brain
Author(s):

Itzhak Fried

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262027205.003.0016

This chapter describes the use of intraoperative microelectrode recordings and microstimulation in thalamus to study the effects of high frequency stimulation on the neural activity of thalamic neurons. In many neurons a high-frequency stimulus train (100-333Hz) was found to be followed by a long period of inhibition, typically longer than 2s. Interestingly, the long-duration inhibition was seen primarily in bursting cells (81% in bursting cells compared to 24% in nonbursting cells). In contrast, at low stimulation rates no inhibition was seen and instead an excitatory response was observed in some neurons. These findings are discussed in terms of possible mechanisms and their relevance to explaining the therapeutic effects of thalamic DBS.

Keywords:   Thalamus, Stimulation, Intraoperative Microelectrode Recording, Bursting activity, Inhibition, DBS

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