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Single Neuron Studies of the Human BrainProbing Cognition$
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Itzhak Fried, Ueli Rutishauser, Moran Cerf, and Gabriel Kreiman

Print publication date: 2014

Print ISBN-13: 9780262027205

Published to MIT Press Scholarship Online: January 2015

DOI: 10.7551/mitpress/9780262027205.001.0001

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Human Single Neuron Recording as an Approach to Understand the Neurophysiology of Seizure Generation

Human Single Neuron Recording as an Approach to Understand the Neurophysiology of Seizure Generation

Chapter:
(p.327) 18 Human Single Neuron Recording as an Approach to Understand the Neurophysiology of Seizure Generation
Source:
Single Neuron Studies of the Human Brain
Author(s):

Itzhak Fried

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262027205.003.0018

Human single neuron recordings can be obtained using either microwire recordings protruding from depth electrodes or using implanted microelectrode arrays during presurgical evaluation of epilepsy patients. As the epileptogenic area is targeted, they may provide useful information on neuronal behaviour during interictal and ictal discharges. Despite the spatial limitations of such recordings, evidence for perifocal neuronal bursting and for highly localized pre-ictal alterations in individual discharge patterns was found using microwire recordings. Microelectrode arrays have shown layer V generators of interictal epileptic spiking and individually stereotyped but highly diverse ictal neuronal discharge patterns, and have provided evidence for a major role of inhibition for postictal depression of neuronal discharges. Human single neuron recordings offer furthermore chances to analyze the specific behaviour and interactions of interneurons and principle neurons to better understand the mechanisms involved in the synchronization of small neuronal clusters during ictiogenesis.

Keywords:   Single neuron recordings, Human, Seizure, Electrophysiology, interictal-ictal transition, microwires, microelectrode array, ictiogenesis

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