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Single Neuron Studies of the Human BrainProbing Cognition$
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Itzhak Fried, Ueli Rutishauser, Moran Cerf, and Gabriel Kreiman

Print publication date: 2014

Print ISBN-13: 9780262027205

Published to MIT Press Scholarship Online: January 2015

DOI: 10.7551/mitpress/9780262027205.001.0001

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Subchronic In Vivo Human Microelectrode Recording

Subchronic In Vivo Human Microelectrode Recording

(p.43) 5 Subchronic In Vivo Human Microelectrode Recording
Single Neuron Studies of the Human Brain

Itzhak Fried

The MIT Press

Progress in neurosurgical procedures and equipment, such as the adaptation of clinical intracerebral electrodes with microelectrodes combined with multi-channel wide bandwidth recording systems, has yielded data with exceptional temporal and spatial resolution used to study single neuron properties of epilepsy and human behavior. Obtaining high fidelity single neuron recordings, however, is demanding and must conform to ethical and safety standards associated with human subject studies. In this context, electrode materials and design, and components of the data acquisition system including headstages, cabling, signal conditioning and analog-to-digital conversion require careful consideration in order to reliably acquire neuronal signals. Here, electrodes and the equipment used to record neuronal activity will be discussed.

Keywords:   Microelectrodes, Microwires, Amplifiers, Headstages, Noise

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