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Computational Psychiatry
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Computational Psychiatry: New Perspectives on Mental Illness

A. David Redish and Joshua A. Gordon

Abstract

Psychiatry is at a crossroads. Faced with challenges of diagnosis and treatment, it must balance analyses at both neurological and psychological levels. Issues of comorbidity, treatment stability, and questions of categorization vs. dimensionality all weigh heavily in current discussions, yet progress has been limited, at best. Computational neuroscience offers a new lens through which to view these issues. This volume presents the results of a unique collaboration between psychiatrists, computational and theoretical neuroscientists, and reveals the synergistic ideas, surprising results, and n ... More

Keywords: Strüngmann Forum Report, computational psychiatry, diagnostic nosology, biomarkers, treatment in psychiatry, computation, neuropsychological processes, failure modes

Bibliographic Information

Print publication date: 2016 Print ISBN-13: 9780262035422
Published to MIT Press Scholarship Online: May 2017 DOI:10.7551/mitpress/9780262035422.001.0001

Authors

Affiliations are at time of print publication.

A. David Redish, editor
University of Minnesota

Joshua A. Gordon, editor
National Institute of Mental Health

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Contents

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Introduction

1 On the Cusp

Joshua A. Gordon and A. David Redish

2 Breakdowns and Failure Modes

A. David Redish and Joshua A. Gordon

Open Issues in Psychiatry

3 Complexity and Heterogeneity in Psychiatric Disorders

Nelson Totah, Huda Akil, Quentin J. M. Huys, John H. Krystal, Angus W. MacDonald III, Tiago V. Maia, Robert C. Malenka, and Wolfgang M. Pauli

Computation

5 Computational Approaches for Studying Mechanisms of Psychiatric Disorders

Zeb Kurth-Nelson, John P. O’Doherty, Deanna M. Barch, Sophie Denève, Daniel Durstewitz, Michael J. Frank, Joshua A. Gordon, Sanjay J. Mathew, Yael Niv, Kerry Ressler, and Heike Tost

Nosology

9 The Computation of Collapse

Angus W. MacDonald III, Jennifer L. Zick, Theoden I. Netoff, and Matthew V. Chafee

10 A Novel Framework for Improving Psychiatric Diagnostic Nosology

Shelly B. Flagel, Daniel S. Pine, Susanne E. Ahmari, Michael B. First, Karl J. Friston, Christoph Mathys, A. David Redish, Katharina Schmack, Jordan W. Smoller, and Anita Thapar

Exemplars

12 Candidate Examples for a Computational Approach to Address Practical Problems in Psychiatry

Rosalyn Moran, Klaas Enno Stephan, Matthew Botvinick, Michael Breakspear, Cameron S. Carter, Peter W. Kalivas, P. Read Montague, Martin P. Paulus, and Frederike Petzschner

14 Call for Pragmatic Computational Psychiatry

Martin P. Paulus, Crane Huang, and Katia M. Harlé

16 Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses

John H. Krystal, Alan Anticevic, John D. Murray, David Glahn, Naomi Driesen, Genevieve Yang, and Xiao-Jing Wang

Conclusion

17 From Psychiatry to Computation and Back Again

A. David Redish and Joshua A. Gordon