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ProtocellsBridging Nonliving and Living Matter$
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Steen Rasmussen, Mark A. Bedau, Liaohai Chen, David Deamer, David C. Krakauer, Norman H. Packard, and Peter F. Stadler

Print publication date: 2008

Print ISBN-13: 9780262182683

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262182683.001.0001

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Parasitism and Protocells: Tragedy of the Molecular Commons

Parasitism and Protocells: Tragedy of the Molecular Commons

17 (p.367) Parasitism and Protocells: Tragedy of the Molecular Commons

Jeffrey J. Tabor

Matthew Levy

Zachary Booth Simpson

Andrew D. Ellington

The MIT Press

This chapter describes the top-down approach of simplifying small or minimal genomes to construct an artificial cell. First, it discusses the concept of minimal genomes. This is followed by an overview of the past and current efforts in comparative and evolutionary genomics. The metabolic capacities of minimal and natural reduced genomes are also discussed. Finally, the chapter outlines possible implications for the assembly of top-down protocells.

Keywords:   artificial cell, minimal genomes, genomics, natural reduced genomes, top-down protocells

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