This chapter explores the techniques for neuronal computation using increasingly refined numerical techniques. It uses an extremely small subset of synaptic signaling event, and considers the signaling circuit at a block diagram, reaction mechanisms, parameters, and solving the model. Some of the signaling-specific issues with parameterization are explained. The chapter examines the ways to fit a biochemical model into the larger context of a neuronal or network model, analyzes how to solve the biochemical model, and then introduces the chemical circuits composed of interacting molecules. It shows that the computations inside a cell provide as much richness, diversity, and challenges as those outside it.
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