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Computational Modeling Methods for Neuroscientists$
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Erik De Schutter

Print publication date: 2009

Print ISBN-13: 9780262013277

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013277.001.0001

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Modeling Voltage-Dependent Channels

Modeling Voltage-Dependent Channels

(p.107) 5 Modeling Voltage-Dependent Channels
Computational Modeling Methods for Neuroscientists

Alain Destexhe

John R. Huguenard

The MIT Press

This chapter describes the voltage-gated ion channels. It considers the different types of formalisms in modeling ionic currents as the action potential and voltage-clamp recordings of the T-type calcium current in thalamic neurons. The chapter specifically reviews the voltage-clamp behavior of the sodium channel and the genesis of action potentials, as well as the characteristics of the T-type calcium current and the genesis of bursts of action potentials by the T-current in thalamic neurons. It shows that nonlinear thermodynamic models offer fits of a quality comparable to empirical Hodgkin-Huxley models, but that their form is physically more plausible.

Keywords:   ion channels, formalisms, ionic currents, voltage-clamp, action potential, calcium current, thalamic neurons, sodium channel, Hodgkin-Huxley models

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