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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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Robustness of Oscillations in Biological Systems

Robustness of Oscillations in Biological Systems

(p.225) 11 Robustness of Oscillations in Biological Systems
Control Theory and Systems Biology

Jongrae Kim

Declan G. Bates

The MIT Press

This chapter takes a robust control approach to the robustness of oscillatory behavior, using oscillations in the social amoeba Dictyostelium as an illustrative example. It uses the proposed methods to examine the robustness of oscillations in the concentration of adenosine 3’, 5’-cyclic monophosphate (cAMP) observed during the aggregation phase of starvation-induced development in Dictyostelium discoideum. It emphasizes the important roles played by stochastic noise in ensuring the robustness of biological oscillations. This chapter shows that the stochastic noise in the Dictyostelium cAMP network represents an important source of robustness to variations between different cells and to changes in their environment.

Keywords:   oscillatory behavior, Dictyostelium discoideum, biological oscillations, adenosine 3’, 5’-cyclic monophosphate, stochastic noise, robustness, aggregation phase

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