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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 26 September 2021

Robustness of Oscillations in Biological Systems

Robustness of Oscillations in Biological Systems

Chapter:
(p.225) 11 Robustness of Oscillations in Biological Systems
Source:
Control Theory and Systems Biology
Author(s):

Jongrae Kim

Declan G. Bates

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262013345.003.0011

This chapter takes a robust control approach to the robustness of oscillatory behavior, using oscillations in the social amoeba Dictyostelium as an illustrative example. It uses the proposed methods to examine the robustness of oscillations in the concentration of adenosine 3’, 5’-cyclic monophosphate (cAMP) observed during the aggregation phase of starvation-induced development in Dictyostelium discoideum. It emphasizes the important roles played by stochastic noise in ensuring the robustness of biological oscillations. This chapter shows that the stochastic noise in the Dictyostelium cAMP network represents an important source of robustness to variations between different cells and to changes in their environment.

Keywords:   oscillatory behavior, Dictyostelium discoideum, biological oscillations, adenosine 3’, 5’-cyclic monophosphate, stochastic noise, robustness, aggregation phase

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