Identification of Biochemical Reaction Networks Using a Parameter-Free Coordinate System
Identification of Biochemical Reaction Networks Using a Parameter-Free Coordinate System
This chapter proposes an observer-based parameter estimation methodology particularly suited for biochemical reaction networks in which the reaction kinetics is described by polynomial or rational functions. It describes the modeling of biochemical reaction networks and the model class considered. It reviews the existing parameter estimation techniques for these models. It uses the proposed methodology to model the mitogen-activated protein kinase (MAPK) cascade. This chapter clearly shows the applicability of the proposed parameter estimation method. This method performs a global parameter search and ensures a guaranteed convergence.
Keywords: observer-based parameter estimation, biochemical reaction networks, mitogen-activated protein kinase, reaction kinetics, polynomial functions, rational functions
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