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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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Quantifying Properties of Cell Signaling Cascades

Quantifying Properties of Cell Signaling Cascades

(p.69) 4 Quantifying Properties of Cell Signaling Cascades
Control Theory and Systems Biology

Simone Frey

Olaf Wolkenhauer

Thomas Millat

The MIT Press

This chapter demonstrates how measures of dynamic behavior can be used to study cell signaling systems. It analyzes the signaling time and signal duration of linear kinase-phosphatase cascades. It illustrates how quantitative measures can be used to investigate features of signaling cascades. This chapter shows how the quantitative signaling measures can be used to investigate various intrinsic properties of signaling cascades. It presents three commonly used models of mitogen-activated protein kinase (MAPK) cascades, representing different levels of approximation. It suggests that the MAPK pathway has evolved into a structure that favors a fast response of short duration to a stimulus.

Keywords:   cell signaling, signal duration, signaling time, quantitative signaling measures, signaling cascades, mitogen-activated protein kinase, dynamic behavior

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