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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 17 September 2021

Quantifying Properties of Cell Signaling Cascades

Quantifying Properties of Cell Signaling Cascades

Chapter:
(p.69) 4 Quantifying Properties of Cell Signaling Cascades
Source:
Control Theory and Systems Biology
Author(s):

Simone Frey

Olaf Wolkenhauer

Thomas Millat

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262013345.003.0004

This chapter demonstrates how measures of dynamic behavior can be used to study cell signaling systems. It analyzes the signaling time and signal duration of linear kinase-phosphatase cascades. It illustrates how quantitative measures can be used to investigate features of signaling cascades. This chapter shows how the quantitative signaling measures can be used to investigate various intrinsic properties of signaling cascades. It presents three commonly used models of mitogen-activated protein kinase (MAPK) cascades, representing different levels of approximation. It suggests that the MAPK pathway has evolved into a structure that favors a fast response of short duration to a stimulus.

Keywords:   cell signaling, signal duration, signaling time, quantitative signaling measures, signaling cascades, mitogen-activated protein kinase, dynamic behavior

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