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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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Control Strategies in Times of Adversity: How Organisms Survive Stressful Conditions

Control Strategies in Times of Adversity: How Organisms Survive Stressful Conditions

Chapter:
(p.85) 5 Control Strategies in Times of Adversity: How Organisms Survive Stressful Conditions
Source:
Control Theory and Systems Biology
Author(s):

Hana El-Samad

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262013345.003.0005

This chapter analyzes the bacterial heat-shock response as a modular controller. It specifically describes the salient organizational properties and design principles of the system in Escherichia coli and highlights the unique insights offered by using a multidisciplinary approach for probing the system. It explains the coordination of the cytoplasmic heat-shock response with other stress-response pathways that act in the cytoplasm or other cellular compartments. It argues that the architecture of the heat-shock response exhibits a level of complexity necessary to satisfy various dynamical performance constraints. This chapter shows that the all bacterial stress systems are implemented through intricate gene regulatory networks that endow them with the dynamical properties that are appropriate for their operation.

Keywords:   bacterial heat-shock, Escherichia coli, cytoplasmic heat-shock response, bacterial stress systems, gene regulatory networks

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