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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 05 July 2022

Synthetic Biology: A Systems Engineering Perspective

Synthetic Biology: A Systems Engineering Perspective

(p.101) 6 Synthetic Biology: A Systems Engineering Perspective
Control Theory and Systems Biology

Domitilla Del Vecchio

Eduardo D. Sontag

The MIT Press

This chapter presents a treatment of “retroactivity to interconnections.” It outlines some of the design challenges found in biomolecular systems from a systems engineering perspective, in particular, the problem of modularity. It proposes a framework for quantifying retroactivity at interconnections between transcriptional circuits and provides a mechanism to counteract retroactivity. This chapter reveals that simple cycles, involving phosphorylation and dephosphorylation, enjoy intrinsic insulation properties, and thus have the potential to serve as synthetic biomolecular insulation devices. It suggests that the design of the biomolecular circuit presents many challenges to systems and control engineers.

Keywords:   biomolecular systems, biomolecular circuit design, modularity, systems engineering, transcriptional circuits, retroactivity, phosphorylation, dephosphorylation, biomolecular insulation devices

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