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Control Theory and Systems Biology$
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Pablo A. Iglesias and Brian P. Ingalls

Print publication date: 2009

Print ISBN-13: 9780262013345

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262013345.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 02 July 2022

A Control-Theoretic Interpretation of Metabolic Control Analysis

A Control-Theoretic Interpretation of Metabolic Control Analysis

(p.145) 8 A Control-Theoretic Interpretation of Metabolic Control Analysis
Control Theory and Systems Biology

Brian P. Ingalls

The MIT Press

This chapter describes the implications of network stoichiometry for sensitivity analysis. It reinterprets the main results of metabolic control analysis (MCA) from the point of view of engineering control theory. The equivalent results are derived from a control-engineering viewpoint, culminating in a control-theoretic interpretation of the main results of metabolic control analysis: the summation and connectivity theorems. It illustrates that MCA offers an extension of standard sensitivity analysis. This chapter bridges the gap between the fields of metabolic control analysis and engineering control theory, further advancing cross-fertilization between these complementary fields.

Keywords:   network stoichiometry, sensitivity analysis, metabolic control analysis, engineering control theory, summation theorem, connectivity theorem, standard sensitivity analysis

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