This chapter narrates the discovery of dendritic spines. It begins with Santiago Ramón y Cajal, a Spanish professor of Pathology and Histology, and his work entitled Estractura delos centros nerviosos de la aves (Structure of the Nervous Centers in Birds) and how he discovered the spines using the Golgi technique. Cajal defined “spine” on the spines of a rose bush, as it resembled one when he first investigated it in Purkinje cells.
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