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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 25 July 2021

A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity

A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity

Chapter:
(p.127) 11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity
Source:
Cerebral Plasticity
Author(s):

Hamilton Andrew

Zito Karen

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0011

This chapter discusses some of the most exciting recent discoveries concerning the mechanisms of spine synapse plasticity and reviews the most intriguing questions which still loom over these tiny cytoplasmic extrusions. It reveals that the sensory experience affects spine motility. This chapter shows that the formation of dendritic spines may be potentiated around sites of high synaptic activity. It supports the hypothesis that spine morphological changes underlie experience-dependent changes in neuronal circuits.

Keywords:   spine synapse plasticity, cytoplasmic extrusions, spine motility, dendritic spines, synaptic activity, neuronal circuits

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