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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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The Glutamate Receptor delta2 Subunit in Cerebellar Wiring

The Glutamate Receptor delta2 Subunit in Cerebellar Wiring

(p.139) 12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring
Cerebral Plasticity

Strata Piergiorgio

Mandolesi Georgia

The MIT Press

This chapter presents a discussion on glutamate receptor delta2 subunit (GluRδ2) in cerebellar wiring. It suggests that GluRδ2 is involved in stabilization and the strengthening of synaptic connectivity between parallel fibers (PFs) and Purkinje cells (PCs). It illustrates that GluRδ2 expression in nonneuronal cells triggers the formation of contacts with granule cell axons and interactions with an unknown presynaptic protein regulate vesicle clustering. The presence of the GluRδ2 is enough to induce the formation of new PF contacts also in cells different from the PCs. This chapter also shows that GluRδ2 has the potential of inducing plastic events in cerebellar circuitry.

Keywords:   glutamate receptor delta2 subunit, cerebellar wiring, parallel fibers, Purkinje cells, synaptic connectivity, nonneuronal cells, granule cell

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