- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
Time Matters
Time Matters
- Chapter:
- (p.247) 20 Time Matters
- Source:
- Cerebral Plasticity
- Author(s):
Singer Wolf
- Publisher:
- The MIT Press
This chapter presents the literature on the role of synaptic plasticity in development and learning. It analyzes the precise timing of spikes matters both in signal processing and synaptic plasticity. It states that cortical networks are capable of exploiting precise temporal relations among the discharges of interconnected neurons both for signal processing and for the induction of use-dependent synaptic gain changes. This chapter supports the hypothesis that oscillations and the associated synchronization of spike discharges play a crucial role in the coordination of distributed neuronal processing, and the gating of synaptic plasticity.
Keywords: synaptic plasticity, precise spike timing, spikes, signal processing, cortical networks, oscillations, neuronal processing, synchronization
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- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
