Show Summary Details
- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation
Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation
- Chapter:
- (p.315) 25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation
- Source:
- Cerebral Plasticity
- Author(s):
Hugh Perry V.
- Publisher:
- The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0025
This chapter deals with the effect of systemic inflammation on neurodegenerative disease. It demonstrates that inflammation may contribute to Alzheimer’s disease (AD) progression. This chapter shows that the interactions between systemic inflammation and the microglia might have a profound influence on the acute and chronic phases of a neurodegenerative disease. It supports the hypothesis that systemic inflammation may accelerate the rate of decline in cognition in patients with AD. It shows that environmental enrichment can have a profound effect on the developing and diseased brain.
Keywords: systemic inflammation, Alzheimer’s disease, microglia, neurodegenerative disease, cognition, environmental enrichment
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- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
