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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 22 October 2021

Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story

Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story

Chapter:
(p.325) 26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story
Source:
Cerebral Plasticity
Author(s):

Cattaneo Antonino

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0026

This chapter describes the connection between the nerve growth factor (NGF) and Alzheimer’s disease (AD). It reveals that NGF can be considered as an anti-amyloidogenic factor that normally keeps the amyloidogenic pathway under control. It states that the experimental study of AD11 neurodegeneration exhibited a novel causal connection between neurotrophic signaling deficits and Alzheimer’s neurodegeneration. This chapter shows the therapeutic potential of the painless NGF molecules, displaying full neurotrophic activity and reduced pain-related signaling capability.

Keywords:   nerve growth factor, Alzheimer’s disease, amyloidogenic pathway, AD11, neurodegeneration, neurotrophic signaling, neurotrophic activity

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