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Cerebral PlasticityNew Perspectives$
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Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

Print publication date: 2011

Print ISBN-13: 9780262015233

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262015233.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 29 June 2022

Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story

Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story

(p.325) 26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story
Cerebral Plasticity

Cattaneo Antonino

The MIT Press

This chapter describes the connection between the nerve growth factor (NGF) and Alzheimer’s disease (AD). It reveals that NGF can be considered as an anti-amyloidogenic factor that normally keeps the amyloidogenic pathway under control. It states that the experimental study of AD11 neurodegeneration exhibited a novel causal connection between neurotrophic signaling deficits and Alzheimer’s neurodegeneration. This chapter shows the therapeutic potential of the painless NGF molecules, displaying full neurotrophic activity and reduced pain-related signaling capability.

Keywords:   nerve growth factor, Alzheimer’s disease, amyloidogenic pathway, AD11, neurodegeneration, neurotrophic signaling, neurotrophic activity

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