- Title Pages
- Preface
- 1 Introduction
- 2 The Dynamic Building of the Brain
- 3 The Plasticity of Retinal Ganglion Cells
- 4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina
- 5 Vision-Dependent Plasticity at the Retinogeniculate Synapse
- 6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System
- 7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders
- 8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling
- 9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases
- 10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction
- 11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity
- 12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring
- 13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity
- 14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration
- 15 The Developmental Process of Acquiring Multisensory Integration Capabilities
- 16 Auditory Processing and Plasticity
- 17 Functional Plasticity of the Auditory Cortex
- 18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine
- 19 What Is Callosal Plasticity?
- 20 Time Matters
- 21 The Two Dorsal Visual Streams and Their Role in Perception
- 22 The Tribal Networks of the Cerebral Cortex
- 23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain
- 24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation
- 25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation
- 26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story
- 27 Neurotrophins as Regulators of Visual Cortical Plasticity
- 28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage
- 29 Suppression of Nogo-A to Enhance CNS Repair
- 30 New Perspectives in the Treatment of Amblyopia
- Contributors
- Index
Neurotrophins as Regulators of Visual Cortical Plasticity
Neurotrophins as Regulators of Visual Cortical Plasticity
- Chapter:
- (p.343) 27 Neurotrophins as Regulators of Visual Cortical Plasticity
- Source:
- Cerebral Plasticity
- Author(s):
Castrén Eero
Fernando Maya Vetencourt José
- Publisher:
- The MIT Press
This chapter describes neurotrophins as regulators of visual cortical plasticity. It illustrates that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are popular candidate molecules for synaptic plasticity. It supports the hypothesis that antidepressant drugs might increase neuronal plasticity in the cortex at least partially by activating BDNF signaling in brain. This chapter also shows the role of antidepressants as enhancers of plasticity, which is consistent with the fact that these drugs are successfully employed for the treatment of many neuropsychiatric disorders in addition to depression, including anxiety, obsessive-compulsive disorder, chronic pain, and eating disorders.
Keywords: neurotrophins, visual cortical plasticity, brain-derived neurotrophic factor, nerve growth factor, synaptic plasticity, antidepressant drugs, neuronal plasticity, cortex
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- Title Pages
- Preface
- 1 Introduction
- 2 The Dynamic Building of the Brain
- 3 The Plasticity of Retinal Ganglion Cells
- 4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina
- 5 Vision-Dependent Plasticity at the Retinogeniculate Synapse
- 6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System
- 7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders
- 8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling
- 9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases
- 10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction
- 11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity
- 12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring
- 13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity
- 14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration
- 15 The Developmental Process of Acquiring Multisensory Integration Capabilities
- 16 Auditory Processing and Plasticity
- 17 Functional Plasticity of the Auditory Cortex
- 18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine
- 19 What Is Callosal Plasticity?
- 20 Time Matters
- 21 The Two Dorsal Visual Streams and Their Role in Perception
- 22 The Tribal Networks of the Cerebral Cortex
- 23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain
- 24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation
- 25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation
- 26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story
- 27 Neurotrophins as Regulators of Visual Cortical Plasticity
- 28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage
- 29 Suppression of Nogo-A to Enhance CNS Repair
- 30 New Perspectives in the Treatment of Amblyopia
- Contributors
- Index
