- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
Suppression of Nogo-A to Enhance CNS Repair
Suppression of Nogo-A to Enhance CNS Repair
- Chapter:
- (p.367) 29 Suppression of Nogo-A to Enhance CNS Repair
- Source:
- Cerebral Plasticity
- Author(s):
Willi Roman
Schwab Martin E.
- Publisher:
- The MIT Press
This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after Nogo-A blockade and its implications for clinical application. This chapter shows that targeting the signaling components by appropriate blockers can prevent growth cone collapse and growth inhibition induced by Nogo-A and several other inhibitors. It also suggests that neutralization of the most potent of inhibitory molecules, Nogo-A, in animal models of spinal cord injury (SCI) and stroke has been shown to be effective in triggering axonal repair mechanisms and behavioral improvements.
Keywords: central nervous system, Nogo-A, signaling pathway, neurite, growth inhibition, spinal cord injury, stroke
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- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
