Show Summary Details
- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases
Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases
- Chapter:
- (p.101) 9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases
- Source:
- Cerebral Plasticity
- Author(s):
Cristo Graziella Di
Chattopadhyaya Bidisha
- Publisher:
- The MIT Press
DOI:10.7551/mitpress/9780262015233.003.0009
This chapter concentrates on the mechanisms regulating the onset of ocular dominance (OD) plasticity. It describes how alteration in the timing of the critical period can be implicated in neurodevelopmental diseases. It reveals a critical role for basket cell interneuron maturation in the onset of critical period plasticity. This chapter shows that maturation of GABAergic inhibition regulates the onset of the critical period for OD plasticity in the visual cortex. It suggests that alterations in molecular pathways involved in regulating critical period plasticity are linked with neurodevelopmental diseases.
Keywords: ocular dominance, plasticity, critical period, neurodevelopmental diseases, basket cell interneuron, GABAergic inhibition, visual cortex, molecular pathways
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- Title Pages
- Preface
-
1 Introduction -
2 The Dynamic Building of the Brain -
3 The Plasticity of Retinal Ganglion Cells -
4 Using Indelible Transgenic Markers to Identify, Analyze, and Manipulate Neuronal Subtypes: Examples from the Retina -
5 Vision-Dependent Plasticity at the Retinogeniculate Synapse -
6 Is Half a Loaf Worse than No Bread?: The Role of Normal and Abnormal Patterns of Neuronal Activity in the Development of the Visual System -
7 Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders -
8 Activity-Dependent Development of Inhibitory Synapses and Innervation Pattern in the Visual Cortex: From BDNF to GABA Signaling -
9 Molecular Factors Controlling Inhibitory Circuit Maturation and Onset of Critical Period Plasticity: Implications for Developmental Diseases -
10 Neuron-Astrocyte Partnership in Brain Function and Dysfunction -
11 A Thorny Question: The Role of Spine Morphogenesis in Adaptive Plasticity -
12 The Glutamate Receptor delta2 Subunit in Cerebellar Wiring -
13 Cortex under Construction: Visual Experience and the Development of Direction Selectivity -
14 Neural Plasticity in Humans: Development of Cross-Orientation Contrast Normalization and Cross-Sensory Calibration -
15 The Developmental Process of Acquiring Multisensory Integration Capabilities -
16 Auditory Processing and Plasticity -
17 Functional Plasticity of the Auditory Cortex -
18 Modulation of Synaptic NMDA Receptors in Striatal Medium Spiny Neurons by Endogenous Dopamine -
19 What Is Callosal Plasticity? -
20 Time Matters -
21 The Two Dorsal Visual Streams and Their Role in Perception -
22 The Tribal Networks of the Cerebral Cortex -
23 Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain -
24 Subcortical Contributions to Cortical Reorganization after Massive Somatosensory Deafferentation -
25 Environmental Influences on Neurodegenerative Disease: The Impact of Systemic Inflammation -
26 Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story -
27 Neurotrophins as Regulators of Visual Cortical Plasticity -
28 Plasticity in the Developing Brain: Functional Reorganization after Early Brain Damage -
29 Suppression of Nogo-A to Enhance CNS Repair -
30 New Perspectives in the Treatment of Amblyopia - Contributors
- Index
