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Schizophrenia: Evolution and Synthesis

Steven M. Silverstein, Bita Moghaddam, and Til Wykes


Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this volume of the Strungmann Forum Reports Series leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment.

Keywords: Schizophrenia, Heterogeneity, Risk, Prevention, Modelling, Treatment, Outcome, Cognition, Rehabilitation

Bibliographic Information

Print publication date: 2013 Print ISBN-13: 9780262019620
Published to MIT Press Scholarship Online: May 2014 DOI:10.7551/mitpress/9780262019620.001.0001


Affiliations are at time of print publication.

Steven M. Silverstein, editor

Bita Moghaddam, editor

Til Wykes, editor

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1 Schizophrenia

Steven M. Silverstein, Bita Moghaddam, and Til Wykes


5 Which Aspects of Heterogeneity Are Useful to Translational Success?

Aiden Corvin, Robert W. Buchanan, William T. Carpenter, James L. Kennedy, Matcheri S. Keshavan, Angus W. MacDonald, Louis Sass, and Michéle Wessa

Risk and Resilience

8 From Epidemiology to Mechanisms of Illness

John McGrath, and Andreas Meyer-Lindenberg

9 How Can Risk and Resilience Factors Be Leveraged to Optimize Discovery Pathways?

Craig Morgan, Michael O’Donovan, Robert A. Bittner, Kristin S. Cadenhead, Peter B. Jones, John McGrath, Steven M. Silverstein, Heike Tost, Peter Uhlhaas, and Aristotle Voineskos


10 Human Cell Models for Schizophrenia

Ashley M. Wilson, and Akira Sawa

13 How Can Models Be Better Utilized to Enhance Outcome?

Kevin J. Mitchell, Patricio O’Donnell, Daniel Durstewitz, André A. Fenton, Jay A. Gingrich, Joshua A. Gordon, Wolfgang Kelsch, William A. Phillips, and Akira Sawa

Development and Treatment

17 What Is Necessary to Enhance Development and Utilization of Treatment?

Vera A. Morgan, Richard Keefe, René S. Kahn, Anil K. Malhotra, Andreas Meyer-Lindenberg, Kim T. Mueser, Karoly Nikolich, Wulf Rössler, William Spaulding, Sharmili Sritharan, and Til Wykes