Jump to ContentJump to Main Navigation
SchizophreniaEvolution and Synthesis$
Users without a subscription are not able to see the full content.

Steven M. Silverstein, Bita Moghaddam, and Til Wykes

Print publication date: 2013

Print ISBN-13: 9780262019620

Published to MIT Press Scholarship Online: May 2014

DOI: 10.7551/mitpress/9780262019620.001.0001

Show Summary Details
Page of

PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 29 June 2022

What Dimensions of Heterogeneity Are Relevant for Treatment Outcome?

What Dimensions of Heterogeneity Are Relevant for Treatment Outcome?

(p.63) 4 What Dimensions of Heterogeneity Are Relevant for Treatment Outcome?

Leanne M. Williams

Chloe Gott

The MIT Press

Schizophrenia is a disorder, or a class of disorders, of cognition. Defining features include a loss of coordination in core perception, attention, memory, and executive functions together with the dysregulation of emotion. These features are the strongest contributors to burden of illness. Diagnostic criteria, clinical trials, and popular conceptions typically focus, however, on the more florid positive symptoms of psychosis, such as hallucinations. As a result, impairments in cognitive–emotional function remain largely undiagnosed and untreated, with no current treatments in routine use that target these impairments. The evidence base for developing new treatments requires cognitive–emotional measures that link to functional capacity as well as to brain changes involved in schizophrenia pathophysiology. This chapter looks at five aspects of cognitive–emotional function in schizophrenia: Which cognitive–emotional impairments characterize schizophrenia patients at first onset? Are functional capacities predicted by these impairments at first onset? What brain systems are involved? How do cognitive–emotional impairments, and their relationships with functional capacity and brain function, progress over time? What are the implications for treatment outcomes? Focus is on the first episode of schizophrenia, since early intervention is likely to have the best impact for improving outcomes. Published in the Strungmann Forum Reports Series.

Keywords:   Schizophrenia, Cognition, Emotion, Treatment, First Episode, Functional Capacity, Outcome, Cognitive Neuroscience

MIT Press Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us.