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Single Neuron Studies of the Human Brain – Probing Cognition - MIT Press Scholarship Online
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Single Neuron Studies of the Human Brain: Probing Cognition

Itzhak Fried, Ueli Rutishauser, Moran Cerf, and Gabriel Kreiman


In the last decade, the synergistic interaction of neurosurgeons, engineers, and neuroscientists, combined with new technologies, has enabled scientists to study the awake, behaving human brain directly. These developments allow cognitive processes to be characterized at unprecedented resolution: single neuron activity. Direct observation of the human brain has already led to major insights into such aspects of brain function as perception, language, sleep, learning, memory, action, imagery, volition, and consciousness. In this volume, experts document the successes, challenges, and opportunit ... More

Keywords: Human single neuron, Neuroscience methods, Memory, Cognition, Consciousness, Perception, Epilepsy

Bibliographic Information

Print publication date: 2014 Print ISBN-13: 9780262027205
Published to MIT Press Scholarship Online: January 2015 DOI:10.7551/mitpress/9780262027205.001.0001


Affiliations are at time of print publication.

Itzhak Fried, editor
UCLA School of Medicine

Ueli Rutishauser, editor

Moran Cerf, editor

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1 Introduction

Itzhak Fried, Ueli Rutishauser, Moran Cerf, and Gabriel Kreiman


5 Subchronic In Vivo Human Microelectrode Recording

Richard J. Staba, Tony A. Fields, Eric J. Behnke, and Charles L. Wilson

II Cognitive Neuroscience Findings and Insights

8 Visual Cognitive Adventures of Single Neurons in the Human Medial Temporal Lobe

Florian Mormann, Matias J. Ison, Rodrigo Quian Quiroga, Christof Koch, Itzhak Fried, and Gabriel Kreiman

10 Microelectrode Studies of Human Sleep

Yuval Nir, Michel Le Van Quyen, Giulio Tononi, and Richard J. Staba

11 Studying Thoughts and Deliberations Using Single Neuron Recordings inHumans

Moran Cerf, Hagar Gelbard-Sagiv, and Itzhak Fried

12 Human Single Neuron Reward Processing in the Basal Ganglia and Anterior Cingulate

Shaun R. Patel, Demetrio Sierra-Mercado, Clarissa Martinez-Rubio, and Emad N. Eskandar

13 Electrophysiological Responses to Faces in the Human Amygdala

Ralph Adolphs, Hiroto Kawasaki, Oana Tudusciuc, Matthew Howard III, Chris Heller, William Sutherling, Linda Philpott, Ian Ross, Adam N. Mamelak, and Ueli Rutishauser


15 Microelectrode Recordings in Deep Brain Stimulation Surgery

C. Rory Goodwin, Travis S. Tierney, Frederick A. Lenz, and William S. Anderson

16 Microstimulation Effects on Thalamic Neurons

Sanjay Patra, William D. Hutchison, Clement Hamani, Mojgan Hodaie, Andres M. Lozano, and Jonathan O. Dostrovsky

Iv Conclusions

19 The Next Ten Years and Beyond

Ueli Rutishauser, Itzhak Fried, Moran Cerf, and Gabriel Kreiman

End Matter