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Pathways to PeaceThe Transformative Power of Children and Families$
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James F. Leckman, Catherine Panter-Brick, and Rima Salah

Print publication date: 2014

Print ISBN-13: 9780262027984

Published to MIT Press Scholarship Online: May 2015

DOI: 10.7551/mitpress/9780262027984.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 04 July 2022



Significance of the Gene-Environment Interface for Brain Development

(p.65) 5 Epigenetics
Pathways to Peace

Eric B. Keverne

The MIT Press

Brain development in humans extends over a very lengthy time period, initially in utero and subsequently embracing attachment interactions with the mother, social interactions with peers, and the emotional turmoil of puberty. Puberty is a period of development when those cortical regions concerned with forward planning and emotional control undergo synaptic pruning and reorganization of connection strengths. Each life phase is developmentally important in shaping and being shaped by the maternal and social environments. Although genetics forms the scaffold for brain development, the detail of connectivities is determined by the kind of environment in which the brain functions. The brain, more than any other organ, is a product of gene-environment interaction. It is a product of the pre- and postnatal niche in which individuals develop and survive. This chapter examines the developmental life phases of the human brain. Published in the Strungmann Forum Reports Series.

Keywords:   brain development, neural connectivities, puberty, gene-environment interactions

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