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Trace Metals and Infectious Diseases$
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Jerome O. Nriagu and Eric P. Skaar

Print publication date: 2015

Print ISBN-13: 9780262029193

Published to MIT Press Scholarship Online: May 2016

DOI: 10.7551/mitpress/9780262029193.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 01 August 2021

Competition for Metals among Microbes and Their Host

Competition for Metals among Microbes and Their Host

Chapter:
(p.29) 3 Competition for Metals among Microbes and Their Host
Source:
Trace Metals and Infectious Diseases
Author(s):

Michael A. Bachman

Jeffrey N. Weiser

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262029193.003.0003

Both microorganisms and their eukaryotic hosts must acquire and compete for metal ions, often from scarce environmental sources, for their metabolism. Since metal ions can also be toxic, their cellular levels must be precisely regulated. The battle over these nutrients may affect the balance between microbe and host, impacting inflammatory responses and determining the outcome of this relationship during colonization and disease. This chapter examines aspects of the thrust and parry among bacteria residing in a host, and between bacteria and their host over metals.

Keywords:   competition for essential metals, nutrient supplementation, inflammation, microbial metabolism, iron sequestration, siderophore production

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