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Trace Metals and Infectious Diseases$
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Jerome O. Nriagu and Eric P. Skaar

Print publication date: 2015

Print ISBN-13: 9780262029193

Published to MIT Press Scholarship Online: May 2016

DOI: 10.7551/mitpress/9780262029193.001.0001

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Competition for Metals among Microbes and Their Host

Competition for Metals among Microbes and Their Host

(p.29) 3 Competition for Metals among Microbes and Their Host
Trace Metals and Infectious Diseases

Michael A. Bachman

Jeffrey N. Weiser

The MIT Press

Both microorganisms and their eukaryotic hosts must acquire and compete for metal ions, often from scarce environmental sources, for their metabolism. Since metal ions can also be toxic, their cellular levels must be precisely regulated. The battle over these nutrients may affect the balance between microbe and host, impacting inflammatory responses and determining the outcome of this relationship during colonization and disease. This chapter examines aspects of the thrust and parry among bacteria residing in a host, and between bacteria and their host over metals.

Keywords:   competition for essential metals, nutrient supplementation, inflammation, microbial metabolism, iron sequestration, siderophore production

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