Jump to ContentJump to Main Navigation
Trace Metals and Infectious Diseases$
Users without a subscription are not able to see the full content.

Jerome O. Nriagu and Eric P. Skaar

Print publication date: 2015

Print ISBN-13: 9780262029193

Published to MIT Press Scholarship Online: May 2016

DOI: 10.7551/mitpress/9780262029193.001.0001

Show Summary Details
Page of

PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 24 June 2022

Common Mechanisms of Bacterial Metal Homeostasis

Common Mechanisms of Bacterial Metal Homeostasis

(p.57) 5 Common Mechanisms of Bacterial Metal Homeostasis
Trace Metals and Infectious Diseases

James A. Imlay

The MIT Press

Transition metals are required for the function of nearly half the enzymatic machinery of organisms. Metals compete for enzyme-binding sites and inappropriate metallation inhibits enzyme function. Thus microbes work hard to acquire, balance, and sort their metal pools. This chapter surveys common tactics by which bacteria control intracellular iron, manganese, copper, and zinc. Focus is on Escherichia coli, for which enough information is available to attempt an integrated view. High-affinity import systems are regulated at the level of transcription by specific metal-sensing transcription factors. If these importers are insufficient, then metal-sparing strategies are engaged for iron and zinc, the two metals needed to activate essential enzymes. At the other extreme, metal overload can result in chemical injuries (Fe, Zn, Cu) and the mismetallation of noncognate enzymes (Fe, Zn, Mn). Export systems are induced to avoid these outcomes. Cu movement may sometimes be chaperone driven, but other metals may reversibly sample protein-binding sites and populate them according to the relative binding strengths of proteins and competing metabolite ligands. Thus metal pool sizes must be controlled and balanced.

Keywords:   metal availability, metal acquisition, metal control, Escherichia coli, metal overload

MIT Press Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us.