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Trace Metals and Infectious Diseases$
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Jerome O. Nriagu and Eric P. Skaar

Print publication date: 2015

Print ISBN-13: 9780262029193

Published to MIT Press Scholarship Online: May 2016

DOI: 10.7551/mitpress/9780262029193.001.0001

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Intervention Strategies for Metal Deficiency and Overload

Intervention Strategies for Metal Deficiency and Overload

Chapter:
(p.83) 6 Intervention Strategies for Metal Deficiency and Overload
Source:
Trace Metals and Infectious Diseases
Author(s):

Fudi Wang

Lihong Zhang

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262029193.003.0006

An increasing amount of evidence shows the linkage between metal ion homeostasis and human disease. Deficiency or overload of metal ions play vital roles in many human diseases, including infectious disease. Nutritional supplementation and metal-based drugs have been suggested as potential intervention strategies to develop treatment for various diseases related to metal deficiency and overload. However, there are numerous forms of metal ion supplementation and metal-based drugs with different features. This chapter provides an overview of the Recommended Daily Allowance, tolerable upper intake levels, and bioavailability of metal elements and offers perspectives on intervention strategies for metal deficiency and overload. Data for analysis were obtained from research articles, reviews, and reports from the World Health Organization; the National Academic Press websites were another principal source of data.

Keywords:   metal ion homeostasis, infectious disease, metal deficiency, metal overload, nutritional supplementation, metal-based drugs, RDAs, tolerable upper intake levels, intervention strategies

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