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Trace Metals and Infectious Diseases$
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Jerome O. Nriagu and Eric P. Skaar

Print publication date: 2015

Print ISBN-13: 9780262029193

Published to MIT Press Scholarship Online: May 2016

DOI: 10.7551/mitpress/9780262029193.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 24 October 2021

Trace Metals in Host–Microbe Interactions

Trace Metals in Host–Microbe Interactions

The Microbe Perspective

Chapter:
(p.99) 7 Trace Metals in Host–Microbe Interactions
Source:
Trace Metals and Infectious Diseases
Author(s):

Jennifer S. Cavet

Robert D. Perry

Sascha Brunke

K. Heran Darwin

Carol A. Fierke

James A. Imlay

Michael E. P. Murphy

Anthony B. Schryvers

Dennis J. Thiele

Jeffrey N. Weiser

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262029193.003.0007

Microbes must acquire metals for metabolic processes, with nearly a half of all enzymes requiring a metal cofactor for function, yet microbes can be poisoned by metals. The host innate immune defenses are thought to exploit these vulnerabilities to protect against invading pathogens, whereas microbes can respond by employing multiple strategies to maintain their metal homeostasis. Understanding these microbial strategies combined with knowledge of diverse metal challenges faced by different microbes in the various host niches could inform the development of new approaches for combating infectious diseases. This chapter summarizes extensive discussions on the interplay of metal ions in host–microbe interactions, from the microbial perspective. Focus is on five key areas: (a) how we define and determine metal availability, (b) the different levels and sources of metals available to microbes in different niches within the host, (c) the effect of the metal status of a pathogen, as derived from its prior environment, on its ability to establish an infection or the severity of disease, (d) the interplay between metals and the microbiota, and (e) how metal restriction and metal oversupply can kill or inhibit the growth of microbes.

Keywords:   immune response to metals, metal ion homeostasis, infectious disease, host–microbe–metal interactions, metal availability, metal restriction, metal oversupply

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