Jump to ContentJump to Main Navigation
Trace Metals and Infectious Diseases$
Users without a subscription are not able to see the full content.

Jerome O. Nriagu and Eric P. Skaar

Print publication date: 2015

Print ISBN-13: 9780262029193

Published to MIT Press Scholarship Online: May 2016

DOI: 10.7551/mitpress/9780262029193.001.0001

Show Summary Details
Page of

PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 03 July 2022

Obesity, Trace Metals, and Infection

Obesity, Trace Metals, and Infection

(p.185) 12 Obesity, Trace Metals, and Infection
Trace Metals and Infectious Diseases

Jerome O. Nriagu

The MIT Press

Trace metals are required in small quantities for a wide array of metabolic functions in the body. In terms of obesity, they can enhance insulin action through activating insulin receptor sites, serve as cofactors or components for enzyme systems involved in glucose metabolism, increase insulin sensitivity, and act as antioxidants to prevent tissue oxidation. Chronic hyperglycemia causes significant alterations in the status of many trace metals in the body and consequently increases the oxidative stress which can contribute to the pathogenesis of infectious diseases. Whether obese individuals with trace metal deficiency (or toxicity) are at increased risk for infection is a matter of concern in many developing countries, where a growing segment of the population (exposed to traditional health risks) has embraced Western dietary habits. A better understanding of the roles of different trace metals will undoubtedly facilitate the development of new treatment and prevention strategies that can more effectively reduce the silent burden of comorbid obesity and infectious diseases.

Keywords:   obesity, insulin, glucose metabolism, tissue oxidation, chronic hyperglycemia, trace metal deficiency, infectious disease, human diet

MIT Press Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us.