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Trace Metals and Infectious Diseases

Jerome O. Nriagu and Eric P. Skaar


Many parts of the world endemic for the most common infectious diseases have the highest prevalence rates of trace metal deficiencies and increasing rates of trace metal pollution. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions. Infectious diseases can increase human susceptibility to adverse effects of metal exposure while metal excess or deficiency can increase the incidence or severity of infectious diseases. The combined effects of exposure to metals and ... More

Keywords: trace metal deficiencies, trace metal toxicity, infectious diseases, trace metal exposure, homeostatic mechanisms, pathogenesis of infectious disease, pathogen-metal interactions

Bibliographic Information

Print publication date: 2015 Print ISBN-13: 9780262029193
Published to MIT Press Scholarship Online: May 2016 DOI:10.7551/mitpress/9780262029193.001.0001


Affiliations are at time of print publication.

Jerome O. Nriagu, editor
University of Michigan

Eric P. Skaar, editor

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1 Introduction

Jerome O. Nriagu and Eric P. Skaar

Host–Microbe Interactions: The Microbe Perspective

2 Is Metal Uptake Related to Ecological Niche in the Vertebrate Host?

Joseph Lemire, Trevor F. Moraes, Vahid Fa Andisi, and Anthony B. Schryvers

3 Competition for Metals among Microbes and Their Host

Michael A. Bachman and Jeffrey N. Weiser

4 The Fate of Intracellular Metal Ions in Microbes

Slade A. Loutet, Anson C. K. Chan, Marek J. Kobylarz, Meghan M. Verstraete, Stephanie Pfaffen, Bin Ye, Angel L. Arrieta, and Michael E. P. Murphy

7 Trace Metals in Host–Microbe Interactions

Jennifer S. Cavet, Robert D. Perry, Sascha Brunke, K. Heran Darwin, Carol A. Fierke, James A. Imlay, Michael E. P. Murphy, Anthony B. Schryvers, Dennis J. Thiele, and Jeffrey N. Weiser

Host–Microbe Interactions: The Host Perspective

10 Metal-Based Antiparasitic Therapeutics

Maribel Navarro and Gonzalo Visbal

13 Metals in Host–Microbe Interaction

Dieter Rehder, Robert E. Black, Julia Bornhorst, Rodney R. Dietert, Victor J. DiRita, Maribel Navarro, Robert D. Perry, Lothar Rink, Eric P. Skaar, Miguel C. P. Soares, Dennis J. Thiele, Fudi Wang, Günter Weiss, and Inga Wessels

Metals in the Environment as Risk Factors for Infectious Diseases

14 Selenium and Mercury

Tamara García-Barrera

15 New Technologies Using Trace Metals of Concern

Jozef M. Pacyna, Kyrre Sundseth, and Elisabeth G. Pacyna

16 The Promise of Nanometals

Mian Wang, Wenwen Liu, and Thomas J. Webster

17 Metals in the Environment as Risk Factors for Infectious Diseases

M. Leigh Ackland, Julia Bornhorst, George V. Dedoussis, Rodney R. Dietert, Jerome O. Nriagu, Jozef M. Pacyna, and John M. Pettifor

Methods and Technologies for Analyzing Trace Metals in Biological Systems

19 Measuring Metals in Complex Biological Systems

Andreas Matusch, Ana-Maria Oros-Peusquens, and J. Sabine Becker

20 Methods and Technologies for Studying Metals in Biological Systems

Wolfgang Maret, Joseph A. Caruso, Christopher H. Contag, David P. Giedroc, Peter-Leon Hagedoorn, Andreas Matusch, Eric P. Skaar, and Richard B. Thompson