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Translational NeuroscienceToward New Therapies$
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Karoly Nikolich and Steven E. Hyman

Print publication date: 2015

Print ISBN-13: 9780262029865

Published to MIT Press Scholarship Online: September 2016

DOI: 10.7551/mitpress/9780262029865.001.0001

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Pathophysiological Toolkit

Pathophysiological Toolkit

Genes to Circuits

(p.139) 10 Pathophysiological Toolkit
Translational Neuroscience

Gül Dölen

Robert C. Malenka

Joel S. Perlmutter

Nils Brose

Richard Frackowiak

Bruce N. Cuthbert

Ilka Diester

Isabelle Mansuy

Katja S. Kroker

Tobias M. Boeckers

Alvaro Pascual-Leone

Guoping Feng

The MIT Press

Understanding the etiology and pathophysiology of neuropsychiatric disease requires the development of new tools (ranging from evolving diagnostic strategies to biomarkers) that can address the unique challenges of neuropsychiatric disease, including the current lack of tractable interfaces between what we can learn in the clinic and the tools available using model systems in the laboratory. This chapter outlines some of these tools, addressing pitfalls and opportunities, while acknowledging the iterative nature of bridging the gaps between different levels of inquiry.

Keywords:   Strüngmann Forum Reports, translational neuroscience, neuropsychiatric disease, biomarkers, RDoC

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