Jump to ContentJump to Main Navigation
Translational NeuroscienceToward New Therapies$
Users without a subscription are not able to see the full content.

Karoly Nikolich and Steven E. Hyman

Print publication date: 2015

Print ISBN-13: 9780262029865

Published to MIT Press Scholarship Online: September 2016

DOI: 10.7551/mitpress/9780262029865.001.0001

Show Summary Details
Page of

PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 24 June 2022

Neurodegenerative Diseases

Neurodegenerative Diseases

Where Are We Not Looking for Answers?

Chapter:
(p.59) 5 Neurodegenerative Diseases
Source:
Translational Neuroscience
Author(s):

Walter J. Koroshetz

Lennart Mucke

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262029865.003.0005

As life expectancy increases, burden of illness soars. The growing magnitude of the health problem and numerous failed trials of agents once considered worth investment (e.g., Alzheimer, Parkinson, and Huntington diseases) demand critical examination. Neurodegeneratives diseases are more complicated than previously thought, and assumptions based on imperfect or incomplete information from animal models are flawed. There is, however, renewed optimism that science will be able to provide relief. This chapter considers existing scientific gaps in effective treatments for neurodegeneration. Discoveries that present tantalizing therapeutic hypotheses are viewed as pieces of a puzzle. At its core, neurodegeneration is a problem of cell health. Importantly, cells are interrelated within the brain, and thus study cannot be limited to one type of cell. Neurodegenerative diseases must be considered as disorders of nervous system circuits, with patients’ symptoms manifestations of neural circuit dysfunction. Successful treatment needs to normalize the biology within individual cells and tissue, and preserve or repair the information processing in important neural circuits. This places new biologic discoveries in perspective and promotes discussion of gaps that stand between discoveries and knowledge of neurodegeneration in overall tissues and circuit dysfunction that eventuates clinically.

Keywords:   Strüngmann Forum Reports, translational neuroscience, age-dependent neurodegeneration, Alzheimer, Parkinson, Huntington, neural circuit dysfunction, animal models

MIT Press Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us.