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Translational Neuroscience – Toward New Therapies - MIT Press Scholarship Online
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Translational Neuroscience: Toward New Therapies

Karoly Nikolich and Steven E. Hyman


Translational neuroscience faces considerable challenges, as available therapies to treat brain and nervous system disorders are extremely limited and dated. Drug efficacy for depression, anxiety, schizophrenia, and bipolar disorder plateaued nearly a half century ago, and further development has all but been abandoned by the pharmaceutical industry. Disinvestment by the private sector has occurred just as promising new technologies in genomics, stem cell biology, and neuroscience have emerged which, if invested in, could initiate a new generation of treatments. This unique paradox clouds the ... More

Keywords: Strüngmann Forum Reports, translational neuroscience, diagnostics, biomarkers

Bibliographic Information

Print publication date: 2015 Print ISBN-13: 9780262029865
Published to MIT Press Scholarship Online: September 2016 DOI:10.7551/mitpress/9780262029865.001.0001


Affiliations are at time of print publication.

Karoly Nikolich, editor

Steven E. Hyman, editor

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1 Introduction

Karoly Nikolich and Steven E. Hyman

Neurodevelopmental Disorders: A New Beginning

4 Neurodevelopmental Disorders

Stephan Heckers, Steven E. Hyman, Thomas Bourgeron, Bruce N. Cuthbert, Raquel E. Gur, Cynthia Joyce, Andreas Meyer-Lindenberg, Michael J. Owen, and Matthew W. State

Neurodegenerative Diseases: Coming Unstuck

5 Neurodegenerative Diseases

Walter J. Koroshetz and Lennart Mucke

7 Neurodegenerative Diseases

David M. Holtzman, Karoly Nikolich, Menelas N. Pangalos, Karl Broich, Nancy Y. Ip, Edward H. Koo, Walter J. Koroshetz, Eliezer Masliah, Lennart Mucke, Pierluigi Nicotera, Mareike Schnaars, and Maria Grazia Spillantini

New Tools to Drive Future Therapies

8 How Might We Get from Genes to Circuits to Disease?

Tobias Kaiser, Yuan Mei, and Guoping Feng

10 Pathophysiological Toolkit

Gül Dölen, Robert C. Malenka, Joel S. Perlmutter, Nils Brose, Richard Frackowiak, Bruce N. Cuthbert, Ilka Diester, Isabelle Mansuy, Katja S. Kroker, Tobias M. Boeckers, Alvaro Pascual-Leone, Guoping Feng

From Cellular and Animal Models to Patients

13 Bridging the Gap between Patients and Models

Ilka Diester, Franz Hefti, Isabelle Mansuy, Alvaro Pascual-Leone, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Marius Wernig, Gül Dölen, Steven E. Hyman, Lennart Mucke, Karoly Nikolich, and Bernd Sommer


14 The Revolution Has Begun

Steven E. Hyman and Karoly Nikolich