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Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes$
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Michael Windle

Print publication date: 2016

Print ISBN-13: 9780262034685

Published to MIT Press Scholarship Online: May 2017

DOI: 10.7551/mitpress/9780262034685.001.0001

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Gene × Environment Interaction in Obesity: The Contribution of Randomized Clinical Trials

Gene × Environment Interaction in Obesity: The Contribution of Randomized Clinical Trials

Chapter:
(p.117) 7 Gene × Environment Interaction in Obesity: The Contribution of Randomized Clinical Trials
Source:
Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes
Author(s):

Jeanne M. McCaffery

Caroline Y. Doyle

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262034685.003.0007

Gene x environment (GxE) interaction is most commonly examined in epidemiologic studies.Yet randomized, controlled trials permit several methodological advantages to the detection of GxE.Primary among these is randomization of the “environmental exposure”, reducing measurement error for the environmental variable as well as confounding due to differences in the exposed relative to unexposed groups, including gene-environment correlation.To the extent that the trial was successful, the exposure exerts a demonstrated environmental main effect on the outcome of interest, providing a fertile ground to detect GxE.In addition, randomized, controlled trials provide the opportunity to look at novel phenotypes critical in the era a Precision Medicine, most notably genetic influences on response to a given treatment.In this chapter, we illustrate the use of randomized, controlled trials to detect GxE with evidence-based behavioral weight loss intervention clinical trials as a prototype.

Keywords:   Gene x environment interaction, Obesity, Randomized, controlled trials, Precision Medicine, Behavioral weight loss

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