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Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes$
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Michael Windle

Print publication date: 2016

Print ISBN-13: 9780262034685

Published to MIT Press Scholarship Online: May 2017

DOI: 10.7551/mitpress/9780262034685.001.0001

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A Statistical Framework for Mediation in Environmental Epigenetics

A Statistical Framework for Mediation in Environmental Epigenetics

Chapter:
(p.251) 11 A Statistical Framework for Mediation in Environmental Epigenetics
Source:
Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes
Author(s):

Duncan C. Thomas

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262034685.003.0011

The biological effects of genes depend upon how they are expressed in target tissues at various points in time, which is determined by their epigenetic state and in turn may be influenced by the environment.Some experimental data suggests that such influences can be transmitted across generations.In this chapter, I propose a general statistical framework for modelling how environmental and germline genetic influences on disease is mediated by epigenetics, both within the individual and across generations.The approach is illustrated on simulated data and on a study of the effect of air pollution and the ARG/NOS family of genes on childhood respiratory disease.

Keywords:   DNA methylation, mediation, statistical genetics, genetic epidemiology, environmental epidemiology, air pollution

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