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Cannabinoids and the Brain$
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Linda A. Parker

Print publication date: 2017

Print ISBN-13: 9780262035798

Published to MIT Press Scholarship Online: September 2017

DOI: 10.7551/mitpress/9780262035798.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 16 September 2021

An Introduction to Cannabis

An Introduction to Cannabis

(p.1) 1 An Introduction to Cannabis
Cannabinoids and the Brain

Linda A. Parker

The MIT Press

Although cannabis has been used throughout human history, the scientific investigation of its effects only began with the isolation of THC in the 1960’s. Once discovered it was another 20 years before the mechanism by which THC produces its psychoactive effects in the brain, the CB1 receptor, was discovered. Cannabis contains over 80 cannabinoid compounds, but THC is the only intoxicating compound. Recent preclinical research is being directed towards evaluating the therapeutic potential of other cannabinoid compounds found in cannabis, including CBD. The pharmacokinetics of THC, methods of administration, and dosing issues are explored in Chapter 1.

Keywords:   Marijuana, Δ‎9-tetrahydrocannabinol, Cannabidiol, Cannabis, Pharmacokinetics, Tolerance

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