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Cannabinoids and the Brain$
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Linda A. Parker

Print publication date: 2017

Print ISBN-13: 9780262035798

Published to MIT Press Scholarship Online: September 2017

DOI: 10.7551/mitpress/9780262035798.001.0001

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Cannabinoids, Learning, and Memory

Cannabinoids, Learning, and Memory

Chapter:
(p.67) 5 Cannabinoids, Learning, and Memory
Source:
Cannabinoids and the Brain
Author(s):

Linda A. Parker

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262035798.003.0005

Global activation of CB1 receptors produces actions on hippocampal neurons, which results in interference with short tem memory and consolidation of memories that are currently being processed. However, such CB1 receptor activation does not impair recall of previously established memories. Evidence suggests that the acute effects of cannabis on memory depend in part on the type of cannabis that is used. THC acts to impair short-term memory and the consolidation of new memories, but CBD protects against the memory impairing effects of THC. There is conflicting human evidence that chronic exposure to cannabis can produce permanent changes in learning and memory processes and/or can modify the human adolescent and adult brain functioning. This evidence is reviewed.

Keywords:   Cognition, Learning, Memory, Conditioning, Hippocampus, Long-term potentiation (LTP)

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