Cannabinoids, Body Weight, Feeding, and Appetite
Cannabinoids, Body Weight, Feeding, and Appetite
The endcoannabinoid system is an important regulator of appetite, food preference and body weight. It not only regulates metabolic feeding related hormones (leptin, ghrelin) in the brain and gut, but also regulates the brain reward circuitry involved in palatability based feeding. One of the primary roles of the endocannabinoid system is in the homeostatic regulation of feeding behaviour. New treatments for obesity are being developed that attempt to harvest the anti-obesity effects of the CB1 antagonist, rimonabant, but that are devoid of the psychiatric side effects that became clearly known only after it was widely prescribed.
Keywords: Rimonabant, CB1 antagonist, Anti-obesity, Appetite, Leptin, Ghrelin, Hypothalamus, Cholesystokinin, Eating disorders, cachexia
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